ea0092ps2-19-02 | Thyroid Hormone Transport & Metabolism Basic | ETA2023
Alevyzaki Androniki
, Markova Boyka
, Mayerl Steffen
, Heuer Heike
Impaired TH transport across brain barriers results in severe TH deficiency in Mct8/Oatp1c1 DKO mice, leading to disturbed neuronal development, myelination as well as locomotor abnormalities. Although brain-barrier associated cells (i.e. endothelial cells, astrocytes, choroid plexus epithelial cells) have been shown to express both transporters, the cell-specific function of Mct8 and Oatp1c1 has still not been defined. Here, we generated and analysed mouse mutants that lack M...